Forsdahl Guro, T. Geisendorfer, G. Gmeiner:
"Quantification and Stability of Salbutamol in Human Urine";
Journal of Separation Science, Vol. 27 (2004), Nr. 1-2; S. 110 - 114.

A sensitive method for the quantification of free salbutamol in human urine is described. Sample clean up is performed using SPE an a mixed phase extraction column. Derivatisation is performed with N-methyl-N-trimethylsilyltrifluoroacetamide (MSTFA) and the extract is analysed by GC-MS. The method was found to be suitable for use in the doping field, where a cut-off limit of 1 ILg salbutamol/mL urine is set by the International Olympic Committee (IOC) and approved by the World Anti-Doping Agency (WADA). Above that value a doping violation occurs. In addition, the stability of salbutamol in human urine has been evaluated.

salbutamol, gas chromatography, mass spectrometry, solid phase extraction, urine, doping

Erstellt aus der Publikationsdatenbank des AIT Austrian Institute of Technology.